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Desk 1 summarizes the observed DLTs by cohort. Somnolence, which fixed in all but one patient, was the one DLT for MLN8054 given with out methylphenidate or modafinil. The onset of somnolence and its severity usually were being correlated with dose and Cmax. For the reason that somnolence was thought to be relevant to Cmax, the dosing plan was alte